Disease burden and treatment patterns in adult patients with severe asthma: A real-world study based on claims data from China | Health Decision

Disease burden and treatment patterns in adult patients with severe asthma: A real-world study based on claims data from China

Authors

  • Ke Zhang
  • Xiaoning He
  • Jing Wu

DOI:

https://doi.org/10.54844/hd.2024.0011

Keywords:

severe asthma, control level, treatment pattern, disease burden, real-world study

Abstract

Objective: To assess the treatment pattern and disease burden in adults with severe asthma in China.

Methods: This retrospective, observational, cohort study with one-year follow-up was conducted using a healthcare claims

database spanning 2018 through 2020, from Tianjin, China. Patients diagnosed with asthma, who had ≥2 prescriptions of

medium-to-high dose of inhaled corticosteroids (ICS) along with additional controllers, were identified to represent severe

asthma population in China. Patients were categorized as controlled, sub-optimally controlled , and uncontrolled by the times

of burst systemic corticosteroids, short-acting β2-agonist (SABA) and hospitalization. Medication use, asthma exacerbations,

and related costs in the follow-up period were also reported.

Results: 2,418 patients with severe asthma were included, with an average age of 56.15 years, male 55.62%. 93.51% of

patients used inhaled corticosteroid/long-acting β2 (ICS/LABA). 10.75% of patients used oral corticosteroids (OCS) (6.13%,

23.83% and 33.96% in controlled, sub-optimally controlled and uncontrolled group, respectively). For patients with OCS,

the average duration of OCS was 82.73 days (53.35, 102.27 and 111.21 days in three groups, respectively). 10.67% of

patients experienced ≥ 1 exacerbation and 3.93% experienced ≥ 2 exacerbations (1.73%,1.68% and 26.89% in three groups,

respectively). The average frequency of annual exacerbations was 0.21 (0.09, 0.26 and 1.31 in three groups, respectively). The

average cost for per exacerbation was ¥1441.83 (¥293.69, ¥550.86 and ¥2366.86 in three groups respectively). The average

asthma-related annual cost was ¥2846.08, of which medication costs exceeded 90% (¥2105.70, ¥3559.35 and ¥8506.83 in

three groups, respectively).

Conclusion: This study shows that ICS/LABA is widely used in patients with severe asthma, and OCS is more used in patients

with uncontrolled asthma. Worse asthma control is associated with more frequent and severe asthma attack and higher medical

cost, which reveals the necessity of effective management and treatment to improve the asthma control.

Key words: severe asthma, control level, treatment pattern, disease burden, real-world study

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Published

2024-07-12

How to Cite

1.
Zhang K, He X, Wu J. Disease burden and treatment patterns in adult patients with severe asthma: A real-world study based on claims data from China. Health Decision. 2024;2(S1). doi:10.54844/hd.2024.0011

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ABSTRACT

Disease burden and treatment patterns in adult patients with severe asthma: A real-world study based on claims data from China


Ke Zhang, Xiaoning He*, Jing Wu

School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China


*Corresponding Author:

Xiaoning He, E-mail: hexn@tju.edu.cn


Received: 15 June 2024 Published: 15 July 2024


ABSTRACT

Objective: To assess the treatment pattern and disease burden in adults with severe asthma in China.

Methods: This retrospective, observational, cohort study with one-year follow-up was conducted using a healthcare claims database spanning 2018 through 2020, from Tianjin, China. Patients diagnosed with asthma, who had ≥2 prescriptions of medium-to-high dose of inhaled corticosteroids (ICS) along with additional controllers, were identified to represent severe asthma population in China. Patients were categorized as controlled, sub-optimally controlled , and uncontrolled by the times of burst systemic corticosteroids, short-acting β2-agonist (SABA) and hospitalization. Medication use, asthma exacerbations, and related costs in the follow-up period were also reported.

Results: 2,418 patients with severe asthma were included, with an average age of 56.15 years, male 55.62%. 93.51% of patients used inhaled corticosteroid/long-acting β2 (ICS/LABA). 10.75% of patients used oral corticosteroids (OCS) (6.13%, 23.83% and 33.96% in controlled, sub-optimally controlled and uncontrolled group, respectively). For patients with OCS, the average duration of OCS was 82.73 days (53.35, 102.27 and 111.21 days in three groups, respectively). 10.67% of patients experienced ≥1 exacerbation and 3.93% experienced ≥2 exacerbations (1.73%,1.68% and 26.89% in three groups, respectively). The average frequency of annual exacerbations was 0.21 (0.09, 0.26 and 1.31 in three groups, respectively). The average cost for per exacerbation was ¥1441.83 (¥293.69, ¥550.86 and ¥2366.86 in three groups respectively). The average asthma-related annual cost was ¥2846.08, of which medication costs exceeded 90% (¥2105.70, ¥3559.35 and ¥8506.83 in three groups, respectively).

Conclusion: This study shows that ICS/LABA is widely used in patients with severe asthma, and OCS is more used in patients with uncontrolled asthma. Worse asthma control is associated with more frequent and severe asthma attack and higher medical cost, which reveals the necessity of effective management and treatment to improve the asthma control.

Key words: severe asthma, control level, treatment pattern, disease burden, real-world study