Respiratory viruses and severe community-acquired pneumonia
Respiratory viruses and severe CAP
Keywords:
Community-acquired pneumonia, respiratory viruses, viral pneumoniaAbstract
Community-acquired pneumonia remains a major cause of morbidity and mortality globally. Streptococcus pneumoniae is recognized the main pathogen related to pneumonia in all site of care. However, recent advances in molecular techniques have led to recognized that respiratory viruses are a common and important cause of severe CAP. Also, in the last 10 years new respiratory viruses are recognized as potential infectious agents in pneumonia. Recent studies show that in approximately 10 to 40% of pneumonia cases are involved viral pathogens being influenza virus the most common respiratory virus. A better knowledge of the role of respiratory viruses especially in cases of severe pneumonia may lead to better management of this population. This review aimed to describe the main respiratory viruses involved in severe pneumonia, specially focus in the clinical presentation, diagnosis, therapy and outcomes.
References
Mandell LA, Wunderink RG, Anzueto A, Bartlett JG, Campbell GD, Dean NC, et al. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis 2007;44 Suppl 2:S27-72.
Riquelme R, Torres A, El-Ebiary M, de la Bellacasa JP, Estruch R, Mensa J, et al. Community-acquired pneumonia in the elderly: A multivariate analysis of risk and prognostic factors. Am J Respir Crit Care Med 1996;154:1450-5.
Musher DM, Roig IL, Cazares G, Stager CE, Logan N, Safar H, et al. Can an etiologic agent be identified in adults who are hospitalized for community-acquired pneumonia: Results of a one-year study. J Infect 2013;67:11-8.
Musher DM, Thorner AR. Community-acquired pneumonia. N Engl J Med 2014;371:1619-28.
Poritz MA, Blaschke AJ, Byington CL, Meyers L, Nilsson K, Jones DE, et al. FilmArray, an automated nested multiplex PCR system for multi-pathogen detection: Development and application to respiratory tract infection. PLoS One 2011;6:e26047.
Luchsinger V, Ruiz M, Zunino E, Martínez MA, Machado C, Piedra PA, et al. Community-acquired pneumonia in chile: The clinical relevance in the detection of viruses and atypical bacteria. Thorax 2013;68:1000-6.
Ohkura N, Tani M, Nishitsuji M, Nishi K. Primary A (H1N1) pdm09 Influenza Pneumonia Diagnosed on Reverse Transcription-polymerase Chain Reaction (RT-PCR) of Bronchoalveolar Lavage Fluid but not Rapid Tests with Nasopharyngeal Swabs. Intern Med 2015;54:1441-5.
Wiemken T, Peyrani P, Bryant K, Kelley RR, Summersgill J, Arnold F, et al. Incidence of respiratory viruses in patients with community-acquired pneumonia admitted to the intensive care unit: Results from the severe influenza pneumonia surveillance (SIPS) project. Eur J Clin Microbiol Infect Dis 2013;32:705-10.
Choi SH, Hong SB, Ko GB, Lee Y, Park HJ, Park SY, et al. Viral infection in patients with severe pneumonia requiring intensive care unit admission. Am J Respir Crit Care Med 2012;186:325-32.
Centers for Disease Control and Prevention (CDC). Bacterial coinfections in lung tissue specimens from fatal cases of 2009 pandemic influenza A (H1N1) - United States, May-August 2009. MMWR Morb Mortal Wkly Rep 2009;58:1071-4.
Paules C, Subbarao K. Influenza. Available from: http://www.thelancet.com. Publishedonline.dx.doi.org/10.1016/S0140-6736(17) 30129-0. [Last accessed on 2017 Mar 13].
Falsey AR. Community-acquired viral pneumonia. Clin Geriatr Med 2007;23:535-52, vi.
Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012;380:2095-128.
Napolitano LM, Angus DC, Uyeki TM. Critically ill patients with influenza A (H1N1) pdm09 virus infection in 2014. JAMA 2014;311:1289-90.
Rothberg MB, Haessler SD, Brown RB. Complications of viral influenza. Am J Med 2008;121:258-64.
Dawood FS, Iuliano AD, Reed C, Meltzer MI, Shay DK, Cheng PY, et al. Estimated global mortality associated with the first 12 months of 2009 pandemic influenza A H1N1 virus circulation: A modelling study. Lancet Infect Dis 2012;12:687-95.
Riquelme R, Riquelme M, Rioseco ML, Inzunza C, Gomez Y, Contreras C, et al. Characteristics of hospitalised patients with 2009 H1N1 influenza in Chile. Eur Respir J 2010;36:864-9.
Riquelme R, Torres A, Rioseco ML, Ewig S, Cillóniz C, Riquelme M, et al. Influenza pneumonia: A comparison between seasonal influenza and H1N1 pandemic. Eur Respir J 2010;36:864-9.
Reed C, Chaves SS, Perez A, D′Mello T, Daily Kirley P, Aragon D, et al. Complications among adults hospitalized with influenza: A comparison of seasonal influenza and the 2009 H1N1 pandemic. Clin Infect Dis 2014;59:166-74.
Riquelme R, Jiménez P, Videla AJ, Lopez H, Chalmers J, Singanayagam A, et al. Predicting mortality in hospitalized patients with 2009 H1N1 influenza pneumonia. Int J Tuberc Lung Dis 2011;15:542-6.
Hui DS, Lee N, Chan PK. Adjunctive therapies and immunomodulatory agents in the management of severe influenza. Antiviral Res 2013;98:410-6.
Louie JK, Yang S, Acosta M, Yen C, Samuel MC, Schechter R, et al. Treatment with neuraminidase inhibitors for critically ill patients with influenza A (H1N1) pdm09. Clin Infect Dis 2012;55:1198-204.
Dunning J, Baillie K, Cao B, Hayden F. Antiviral Combinations for Severe Influenza. Available from: http://www.thelancet.com/infectionPublishedonlinedx.doi.org/10.1016/S1473-3099 (14) 70821-7. [Last accessed on 2014 Sep 09].
Center for Disease Control and Prevention. Available from: https://www.cdc.gov/flu/avianflu/. [Last accessed on 2017 Apr 10].
Center for Disease Control and Prevention. Available from: https://www.cdc.gov/flu/avianflu/prevention.htm. [Last accessed on 2017 Apr 10].
Falsey AR, Hennessey PA, Formica MA, Cox C, Walsh EE. Respiratory syncytial virus infection in elderly and high-risk adults. N Engl J Med 2005;352:1749-59.
Falsey AR, Formica MA, Walsh EE. Diagnosis of respiratory syncytial virus infection: Comparison of reverse transcription-PCR to viral culture and serology in adults with respiratory illness. J Clin Microbiol 2002;40:817-20.
Thompson WW, Shay DK, Weintraub E, Brammer L, Cox N, Anderson LJ, et al. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA 2003;289:179-86.
Center for Disease Control and Prevention. Human Parainfluenza Viruses. Available from: https://www.cdc.gov/parainfluenza/hcp/index.html. [Last accessed on 2017 Apr 10].
Center for Disease Control and Prevention. Human Metapneumovirus (HMPV) Clinical Features. Available from: https://www.cdc.gov/surveillance/nrevss/hmpv/clinical.html. [Last accessed on 2017 Apr 10].
Sun B, He H, Wang Z, Qu J, Li X, Ban C, et al. Emergent severe acute respiratory distress syndrome caused by adenovirus type 55 in immunocompetent adults in 2013: A prospective observational study. Crit Care 2014;18:456.
Alraddadi BM, Al-Salmi HS, Jacobs-Slifka K, Slayton RB, Estivariz CF, Geller AI, et al. Risk factors for middle east respiratory syndrome coronavirus infection among healthcare personnel. Emerg Infect Dis 2016;22:1915-20.
Oboho IK, Tomczyk SM, Al-Asmari AM, Banjar AA, Al-Mugti H, Aloraini MS, et al. 2014 MERS-CoV outbreak in Jeddah - A link to health care facilities. N Engl J Med 2015;372:846-54.
Available from: http://www.cdc.gov/sars. [Last accessed on 2017 Apr 10].
Riquelme R, Rioseco ML, Bastidas L, Trincado D, Riquelme M, Loyola H, et al. Hantavirus pulmonary syndrome, Southern Chile, 1995-2012. Emerg Infect Dis 2015;21:562-8.
Riquelme R, Riquelme M, Torres A, Rioseco ML, Vergara JA, Scholz L, et al. Hantavirus pulmonary syndrome, Southern Chile. Emerg Infect Dis 2003;9:1438-43.
Padula PJ, Edelstein A, Miguel SD, López NM, Rossi CM, Rabinovich RD. Hantavirus pulmonary syndrome outbreak in Argentina: Molecular evidence for person-to-person transmission of Andes virus. Virology 1998;241:323-30.
Downloads
Published
How to Cite
Issue
Section
Downloads
License
Copyright (c) 2017 Raúl Riquelme Oyarzun

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.