Profile of glucose intolerance in HIV-positive patients on 1st line and 2nd line antiretroviral therapy: Profile of glucose intolerance in HIV positive patients

Nischay Ramaswamy; Biplab N. Singh; Bhimo Singh; Asha Basavareddy

Authors

Nischay Ramaswamy Department of Medicine, Manipal Hospital, Bangalore, Karnataka, India
Biplab N. Singh Department of Medicine, Regional Institute of Medical Science, Imphal, Manipur, India
Bhimo Singh Department of Medicine, Regional Institute of Medical Science, Imphal, Manipur, India
Asha Basavareddy Department of Pharmacology, Sri Devaraj Urs Medical College, Tamaka, Kolar, Karnataka, India

Keywords:

Antiretroviral therapy (ART) 1 and 2, glucose profile, lipid profile

Abstract

Background and Aims: Human Immunodeficiency Virus infections have developed into a global pandemic with cases reported from virtually every country. Manipur has also shown an increase in the incidence of HIV/AIDS since the past decade. Thus far, very little data is available in this part of the country about the effect of 1 st and 2 nd line antiretroviral therapy (ART) on the glycemic status of the patients. Hence, this study was undertaken to assess and compare the effect of 1 st line and 2 nd line ART on glycemic status of HIV patients. Subjects and Methods: The study was carried out in the ART centre in Regional Institute of Medical Sciences, Imphal. It was a cross-sectional comparative observational study carried out from October 2010 to September 2012. A total of 292 patients were included in the study, of which 211 patients were receiving ART 1 st line and 81 patients receiving ART 2 nd line. HIV patients receiving ART were investigated for fasting, 2 hours post-prandial glucose, CD4 cell count, total cholesterol, and serum triglyceride levels. Chi-square and Student's t tests were used to find the significance between the two groups. Pearson's correlation between clinical variable and sugar and lipid parameters was performed to find the effect of relationship. Results: The difference between the two groups was statistically significant in Random Blood Sugar (RBS), Fasting Blood Sugar (FBS) and Post Prandial Blood sugar (PPBS) values (P = 0.022; P = 0.004 and P < 0.001 respectively). Patients in Group II had significantly higher values of TC and TG compared to Group I patients with a P value of <0.001. Conclusions: The glucose and lipid parameters were significantly high receiving ART 2 nd line patients in comparison with ART 1 st line patients.

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Profile of glucose intolerance in HIV-positive patients on 1st line and 2nd line antiretroviral therapy