Preparation of Doxorubicin-loaded Polylactic acid/graphene oxide nanofibrous membranes with different structures by electrospinning for cancer therapy

Abstract

Background: Intravenous administration is still often used as adjuvant therapy after breast cancer resection, with toxic side effects. It is important to find a method of local administration to avoid the high cytotoxicity.

Methods: In the paper, a series of polylactic acid (PLA)-based nanofibers loaded with Doxorubicin (DOX) by blended and coaxial electrospinning were prepared to localize anticancer.

Results: Scanning electron microscope (SEM) shows that all nanofibers have smooth surfaces and uniform diameters, and DOX is uniformly dispersed in the fibers.

Conclusions: All electrospun fibers can effectively relieve the release of DOX and possess the ability to kill cells, and the ability of coaxial spinning is better than that of blended spinning.