Preparation of Doxorubicin-loaded Polylactic acid/graphene oxide nanofibrous membranes with different structures by electrospinning for cancer therapy


  • Yanru Hu
  • Li Chen
  • Lihui Meng
  • Wenchao Li
  • Fang Zhu
  • Bin Xie
  • Jiangling Wan
  • Qingzhi Wu State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Biomedical Material and Engineering Center of Hubei Province, Wuhan University of Technology


Doxorubicin; Electrospinning; Anticancer; Nanofibers


Background: Intravenous administration is still often used as adjuvant therapy after breast cancer resection, with toxic side effects. It is important to find a method of local administration to avoid the high cytotoxicity.

Methods: In the paper, a series of polylactic acid (PLA)-based nanofibers loaded with Doxorubicin (DOX) by blended and coaxial electrospinning were prepared to localize anticancer.

Results: Scanning electron microscope (SEM) shows that all nanofibers have smooth surfaces and uniform diameters, and DOX is uniformly dispersed in the fibers.

Conclusions: All electrospun fibers can effectively relieve the release of DOX and possess the ability to kill cells, and the ability of coaxial spinning is better than that of blended spinning.






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