Antidepressants in functional gastrointestinal disorders: a review of recent clinical trials and possible mechanisms

Clinical application and mechanism of antidepressants in FGIDs

Abstract

Functional gastrointestinal disorders (FGIDs), or disorders of brain-gut axis, is a common digestive problem, affecting about 20%-40% of the population. The high prevalence and unclear pathogenesis bring great difficulty to diagnosis and treatment, and cause significant influence and burden to patients and society. Antidepressants are typically used for FGIDs in clinical practice, which draw great attention, with satisfactory effect and safety. This article summaries the application of antidepressants in the treatment of FGIDs and the possible underlying mechanisms.