An uncommon scenario from a common burden

Rare manifestation of tuberculosis

Authors

  • Manipriya Ravindran Department of General Medicine, Sri Ramachandra Medical College, Chennai, Tamil Nadu, India
  • Kawin Gunasekaran Department of General Medicine, Sri Ramachandra Medical College, Chennai, Tamil Nadu, India
  • V. Siva Prakash Department of General Medicine, Sri Ramachandra Medical College, Chennai, Tamil Nadu, India
  • J. Damodharan Department of General Medicine, Sri Ramachandra Medical College, Chennai, Tamil Nadu, India

Keywords:

Hemophagocytic lymphohistiocytosis, Mycobacterium tuberculosis, pancytopenia, tuberculosis

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is an infrequent disorder occurring as a result of unrestrained immune activation. Tuberculosis (TB) is a catastrophic cause of secondary HLH if not treated appropriately. Here, we report an unusual case of secondary HLH associated with abdominal TB. Although rare, secondary HLH should be ruled out in patients with TB, especially in the presence of pancytopenia.

References

Nair N, Wares F, Sahu S. Tuberculosis in the WHO South-East Asia region. Bull World Health Organ 2010;88:164.

Créput C, Galicier L, Buyse S, Azoulay E. Understanding organ dysfunction in hemophagocytic lymphohistiocytosis. Intensive Care Med 2008;34:1177-87.

Bhattacharyya M, Ghosh MK. Hemophagoctic lymphohistiocytosis - Recent concept. J Assoc Physicians India 2008;56:453-7.

Shea YF, Chan JF, Kwok WC, Hwang YY, Chan TC, Ni MY, et al. Haemophagocytic lymphohistiocytosis: An uncommon clinical presentation of tuberculosis. Hong Kong Med J 2012;18:517-25.

Brastianos PK, Swanson JW, Torbenson M, Sperati J, Karakousis PC. Tuberculosis-associated haemophagocytic syndrome. Lancet Infect Dis 2006;6:447-54.

Ishii E, Ohga S, Imashuku S, Yasukawa M, Tsuda H, Miura I, et al. Nationwide survey of hemophagocytic lymphohistiocytosis in Japan. Int J Hematol 2007;86:58-65.

Wang JY, Hsueh PR, Lee LN, Liaw YS, Shau WY, Yang PC, et al. Mycobacterium tuberculosis inducing disseminated intravascular coagulation. Thromb Haemost 2005;93:729-34.

Mancebo E, Allende LM, Guzmán M, Paz-Artal E, Gil J, Urrea-Moreno R, et al. Familial hemophagocytic lymphohistiocytosis in an adult patient homozygous for A91V in the perforin gene, with tuberculosis infection. Haematologica 2006;91:1257-60.

Rajagopala S, Singh N. Diagnosing and treating hemophagocytic lymphohistiocytosis in the tropics: Systematic review from the Indian subcontinent. Acta Med Acad 2012;41:161-74.

Takahashi N, Chubachi A, Kume M, Hatano Y, Komatsuda A, Kawabata Y, et al. A clinical analysis of 52 adult patients with hemophagocytic syndrome: The prognostic significance of the underlying diseases. Int J Hematol 2001;74:209-13.

Downloads

Published

2016-03-23

How to Cite

1.
Ravindran M, Gunasekaran K, Prakash VS, Damodharan J. An uncommon scenario from a common burden: Rare manifestation of tuberculosis. Community Acquir Infect. 2016;3. Accessed May 3, 2025. https://www.hksmp.com/journals/cai/article/view/276

Issue

Section

Case Report

Downloads

Download data is not yet available.