New Special Issue: Gut Microbiota and Brain Diseases: Focusing on Novel Therapy and Therapeutic Targets


Special Issue Editor

Prof. Peijing Rong, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences
Research interests: Integration of Chinese and Western medicine, brain and related disorders, acupuncture and innovation intervention, TCM and interdisciplinary

Prof. Hong Wei, Yu-Yue Pathology Scientific Research Center,Chongqing, China
Research interests: Microbiology and disease, Germ-free mice model and disease, Microbial Pharmacology and disease

Dr. Shaoyuan Li, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences
Research interests: Acupuncture, innovation intervention, brain and related disorders

Dr. Yu Wang, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences
Research interests: Acupuncture; neuropsychiatric disorders; neuroinflammation

Special Issue Information

Dear colleagues,

Brain and related diseases are among the major disorders influencing human health. In general, brain diseases include diseases that might be classified as neurological or psychiatric, for example, Alzheimer’s disease, Parkinson’s disease, epilepsy, depression, autism, and addiction. Patients with these types of diseases are mainly characterized by abnormal thinking patterns, cognition, emotional states, and behavior. To date, much of the research on these diseases has used rodent models. Despite some encouraging findings, the underlying pathophysiological mechanisms, as well as, novel therapy and therapeutic targets are still in urgent need of breakthrough.
It is worth mentioning that since it was first reported in 2011, the reduction of anxiety-like behavior and the changes of neurochemicals in the brain were observed in mice with the absence of gut microbes, resulting in a surge of interest in the role of the gut microbiota in health. And the new concept of microbiota-gut-brain (MGB) axis was formally put forward in 2012, which revealed the ways in which peripheral systems and organs affect the brain, and showed that the periphery and the center can be closely linked through the carriers of gut microbiota. Meanwhile, the increasing number of novel therapies and therapeutic targets keeps emerging based on the above hypothesis.
In light of this, the purpose of this special issue is to invite the scientific community to submit original research papers, reviews, pertaining to the recent advances in the field of novel therapy and therapeutic targets related to gut microbiota and brain diseases. In addition to appealing to a broad audience, contributions should address challenging scientific issues, provide potential therapies, offer insight into how the field is evolving or introduce novel approaches to solving problems.
Potential topics include but are not limited to the following:

Pre-clinical study of pharmacological or non-pharmacological therapies that target gut microbes to improve brain and related diseases;
Strategies and methods for studying the relationship between gut microbiota and the brain and related diseases;
Intervention strategies targeting the gut microbiota and their subsequent translation into clinical trials.

Key words: Brain and related diseases, gut microbiota, microbiota-gut-brain axis, interventions

Guest Editor Team

Manuscript Submission Information

Manuscripts should be submitted at the online system ( All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process.
Please visit the Author Guidelines ( page before submitting a manuscript. Submitted papers should be well formatted and use good English.