Progress in the Pathogenesis of Inflammatory Bowel Disease

Pathogenesis of IBD

Abstract

Inflammatory bowel disease (IBD) is a group of chronic, non-specific, recurrent inflammatory diseases, and also has a cancerous tendency. IBD mainly includes ulcerative colitis (UC) and Crohn's disease (CD), and the incidence of IBD is increasing year by year. Although IBD is believed to be a result of an imbalanced interaction among genetic susceptibility, environmental factors, intestinal microflora, and the immune system, its etiology and pathogenesis have not been fully clarified. Moreover, IBD is closely associated with the initiation and progression of colorectal cancer (CRC). Therefore, the early detection and prevention of IBD are important to prevent carcinogenesis. This review discusses advances in the pathogenesis of IBD, to provide new ideas for the treatment and further development of the new drugs of IBD.