Community Acquired Infection

CAR T-cell structure, manufacturing, applications, and challenges in the management of communityacquired diseases and disorders

Tue, 22 Apr 2025 00:00:00 +0800

This article discusses the groundbreaking potential of chimeric antigen receptor (CAR) T-cell therapy for cancer and its potential downsides. One intriguing method, CAR-modified T-cells, can target a specific cancer cell molecule. It has been gaining popularity worldwide, especially in hematological malignancies. However, resistance mechanisms, antigen loss, a suppressive tumor microenvironment, altered T cell trafficking, and metabolic competition may hinder therapeutic efficacy. Such infusion would improve patient care applications and enable the treatment of solid tumors and other tough diseases, transforming the immunotherapeutic landscape. Next-generation approaches that address present technology limitations are improving CAR T-cell therapy. The novel dual-targeting CAR model is being studied. This model can recognize many antigens, reducing tumor risk from antigen loss. To prepare T cells for success and durability, tumor modification methods are also being studied. In addition to being safer and more effective, CAR T-cell therapy may enable tailored and flexible cancer treatment approaches that could supplement or replace the current healthcare system and spur medical field change.

Infectious diseases: Addressing global challenges and prevention strategies for national health improvement

Miracle Oluwapelumi Falodun, Olaolorunpo Olorunfemi, Omolola Oladunni Irinoye — Mon, 07 Apr 2025 00:00:00 +0800

Infectious diseases remain a significant global health concern, posing substantial challenges in terms of healthcare systems and societal impact. The emergence of new infectious agents and the re-emergence of known pathogens continually present challenges in disease prevention and control worldwide. This study aims to analyze the current landscape of infectious diseases, highlighting their impact on global health and exploring preventive strategies to mitigate their spread and impact. The review paper sourced data from published studies on PubMed, Scopus, and Google Scholar using keywords like infectious diseases, global health, global challenges and prevention strategies. Retrieved literature was screened for eligibility. The literature search considered publications from 2018 to 2024 to focus on variables of the study. In the review Six themes (issues) emerged which are: (1) The Global Impact on Health (2) Factors Contributing to Global Spread (3) Prevention Strategies (4) Global Collaborative Efforts and Interventions (5) Challenges in Prevention and Control (6) Health Belief Model in Conclusion, the study reinforces the significance of a multifaceted and collaborative approach to address the challenges posed by infectious diseases, by implementing the prevention strategies, fostering international cooperation, and leveraging advancements in healthcare technology.

The growing concern of human metapneumovirus

Amruta Balekundri, Eknath D. Ahire — Mon, 19 May 2025 00:00:00 +0800

Human metapneumovirus (hMPV) has recently emerged as a significant respiratory pathogen, garnering increased recognition due to advancements in molecular diagnostic tools that have enhanced its detection and characterization. Traditionally, hMPV has been associated with severe manifestations in pediatric populations, the elderly, and immunocompromised individuals. However, hMPV-related pneumonia in immunocompetent adults remains a relatively underexplored area. This letter aims to underscore the global health importance of hMPV by highlighting a case report and a recent outbreak study. It also emphasizes the necessity for heightened awareness, rapid diagnostics, and the potential development of vaccines to mitigate the impact of this pathogen.