https://www.hksmp.com/cif/issue/feedCancer in Females2025-03-12T00:00:00+08:00Ying Haneditorialoffice@cancerinfemale.comOpen Journal Systems<ul> <li><strong>Background</strong></li> </ul> <p>In recent years, the incidence of cancer in females has increased year by year. In the occurrence and development of female cancer diseases, surgery, chemotherapy, radiotherapy, targeted therapy and immunotherapy have played extremely important roles in the teatment of female cancers. However, there is no peer-reviewed journals focus on this fundamental field.</p> <ul> <li><strong>Aims and Scope</strong></li> </ul> <p>Led by an outstanding Editorial Board of international experts, this journal aims at promoting clinical and experimental research related to cancer in females. The journal publishes clinical guidelines, clinical consensus, special reviews, clinical research, basic research, case reports, short reports, letters from readers, technological progress, continuing medical education, etc.</p> <ul> <li><strong>Target Audience</strong></li> </ul> <p>Audience in the fields of diagnosis and treatment, nursing, research, education, and public policy on females cancer disease including doctors, nurses, and public health personnel, as well as patients.</p> <ul> <li><strong>Covered Disciplines or Sub-disciplines</strong><strong>（> 10 Hot topics should be listed）</strong> <ul> <li>Cervical cancer</li> <li>Ovarian cancer</li> <li>Uterus cancer</li> <li>Vulvar cancer</li> <li>Vaginal cancer</li> <li>Breast cancer</li> <li>Chemotherapy of Cancer in Females</li> <li>Radiotherapy of Cancer in Females</li> <li>Rare diseases of Cancer in Females</li> <li>Metastasis of Cancer in Females</li> <li>Targeted therapy of Cancer in Females</li> <li>Immunotherapy of Cancer in Females</li> </ul> </li> </ul>https://www.hksmp.com/cif/article/view/769The number of lifetime sexual partners may not be associated with cervical cancer: A Mendelian randomization study2024-10-28T10:56:22+08:00Kan Chen476271816@qq.comLi Wan4683019@qq.comFang Wang731127737@qq.comYingxue Liu1425145931@qq.comJinyan Tang2949883359@qq.comLu Hancckk960504@163.com<p><strong>Objective: </strong>The objective of this study was to investigate the causal relationship between the number of lifetime sexual</p> <p>partners (NLSP) and cervical cancer (CC) using the Mendelian randomization (MR) method. <strong>Methods: </strong>Genome-wide</p> <p>association study (GWAS) data on NLSP and CC were obtained from the integrative epidemiology unit open genome-wide</p> <p>association studies (IEU OpenGWAS) project. To assess the correlation between NLSP and CC risk, we employed the</p> <p>inverse-variance weighted (IVW) method, applying a preset threshold to select single nucleotide polymorphisms (SNPs)</p> <p>closely related to NLSP. Instrumental variables (IVs) were constructed using isolated SNPs. Heterogeneity among the SNPs</p> <p>was evaluated using the Cochran Q test. The presence of abnormal SNPs was tested with MR pleiotropy residual sum and</p> <p>outlier test (MR-PRESSO). The Mendelian randomization-Egger (MR-Egger) intercept test was conducted to examine</p> <p>horizontal pleiotropy among the SNPs. Additionally, the "leave-one-out" sensitivity analysis was performed to assess whether</p> <p>the MR results were influenced by any single SNP. <strong>Results: </strong>A total of 63 SNPs correlated with NLSP were screened. IVW</p> <p>analysis revealed no causal relationship between NLSP and CC, with an odds ratio (OR) of 1.001, 95% confidence interval</p> <p>(CI): 0.996 – 1.005, <em>P</em> = 0.797. The Cochran Q test indicated no significant heterogeneity among the included SNPs (Q =</p> <p>73.051, <em>P</em> = 0.07). The MR<em>-</em>Egger intercept value was 1.61×10-5 (<em>P</em> = 0.903), suggesting no genetic pleiotropy among the</p> <p>screened SNPs. MR-PRESSO did not identify any outlier SNPs. Furthermore, the "leave-one-out" sensitivity analysis</p> <p>indicated that the causal estimates were unlikely to be influenced by specific SNP effects. <strong>Conclusion: </strong>Our findings suggest</p> <p>that there may be no causal relationship between the NLSP predicted by genetics and the risk of CC.</p>2025-03-12T00:00:00+08:00Copyright (c) 2025 Cancer in Females